英国桑格研究院病原体基因组学方向博士后招聘

Postdoctoral Scientist - Pathogen Genomics – Ref: 81031 : Cambridgeshire, CB10 1SA, UK
Employer: Wellcome Trust Sanger Institute
Website: http://www.sanger.ac.uk
Location: Cambridgeshire, CB10 1SA, UK
Type: Postdoctoral
Posted: November 11, 2011
Expires: December 11, 2011
Jobs by tag(s): wellcome trust sanger institute hinxton Cambridge molecular biology microbiology salary range is 28280 to 34778
Requisition number: 81031

job description

The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health & disease.

The Pathogen Genomics team, headed by Professor Julian Parkhill, performs large-scale genomic and comparative genomic analyses of bacterial pathogens. The team are investigating a wide range of human and animal pathogens, and currently have over 100 ongoing projects, collaborating widely within the UK and world scientific community. The team has sequenced the genomes of organisms that are of fundamental importance for human health including the causative agents of; tuberculosis, malaria, plague, typhoid fever, sleeping sickness, whooping cough, dengue fever, leprosy, diphtheria and meningitis. Our primary current interests are using new sequencing technologies to investigate bacterial populations to understand transmission and evolution. We also apply high-throughput technologies to the analysis of bacterial phenotypes.

We have recently received MRC funding for a Postdoctoral Scientist, within the Pathogen Genomics team, to work on antibiotic resistance using the latest sequencing technology. The work will involve the investigation of antibiotic resistance mechanisms in pathogenic bacteria, including Salmonella (Typhi and Typhimurium), Enterobacter cloacae, Staphylococcus aureus and Escherichia coli, and will involve the construction of very large transposon mutant libraries consisting of at least 1 million mutants of each of these bacteria. Transposon Directed Insertion Site-sequencing (TraDIS) will then be used to identify all candidate essential genes, and thereafter to assay simultaneously every gene in the respective genomes for involvement in resistance to a number of different antibiotics. This involves mapping the TraDIS sequence reads to reference genomes using in-house software and large computer clusters running the UNIX operating system.

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Essential Skills
• PhD in Microbiology
• Ability to work as part of a team with minimal supervision
• Extensive molecular biology experience
• Excellent organisational skills
• Experience of working at biological containment level 2
• Extensive knowledge of molecular microbiology

Ideal Skills
• Preparation of DNA fragment libraries for Illumina sequencing
• Analysis of large sets of short-read sequence data
• Familiarity with the UNIX operating system

Other information
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. This is a three year fixed-term contract. Successful applicant(s) who have submitted their PhD thesis and are awaiting their PhD award to be confirmed will be placed on a transitional pay point, currently £26,103. On confirmation applicants will be moved on to the pay scale above.

Benefits
The Institute has excellent purpose built facilities on the Genome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk,

To submit your CV and apply for this job please go to https://jobs.sanger.ac.uk, to register and apply on line.]

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Salary range is £28,280 to £34,778 per annum dependent on experience. Closing Date: 11th December 2011