新加坡南洋理工大学化学与生物医学学院招聘博

Postdoctoral Research Fellow in Biosurface Engineering (http://www3.ntu.edu.sg/home/dhkim/index.html)
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Applications are invited for the above post, funded by a grant from Singapore Government Research Development Fund and based in the School of Chemical and Biomedical Engineering, Nanyang Technological University in Singapore.

Areas of interest: We are looking for post-doctoral research fellows to carry out research in
1) Nanophotonics (LSPR, SERC with either chemical or physical background (preferably optics related area))
2) Microfluidics
3) Materials for Energy-related research.

Applicants must submit a curriculum vitae and names of three references. All materials should be sent to: Professor Kim at dhkim@ntu.edu.sg.

Introduction of the lab:
Research

BSE lab focuses on biomaterial surface science/engineering, specifically surface engineering of implantable biosensors and bioanalytical platforms.
Immune-modulating surface coatings to enhance long term performance of neural prostheses  
Engineer surfaces that present immune-modulating biomolecules at molecular levels and exploit their functional effects on cellular behavior. This research is motivated by the realization that protein layers non-specifically adsorbed to the surface of implanted biomaterials differ substantially in composition and conformation from the proteins that comprise the extracellular matrix and the surfaces of cells. As a result, these non-specifically adsorbed layers both induce inflammation and lack the ligands that reduce inflammation.   
Biomolecule release from neural prosthetic devices  
Nanopatterns for Directed Neuronal Growth  
Develop nanopatterned surfaces that guide/stimulate neural process growth toward implanted recording electrodes and quantitatively analyze the growth behavior of neural processes. Damaged brain tissue is difficult to repair or regenerate. Attraction of neurons or neural processes toward the electrodes will increase the stability of implanted electrodes, promoting better neural recording for the development of a long-term neural prosthesis. The proof-of-concept for applying growth factors to attract neurons toward the implanted electrode has now been established with results showing increased in-growth of neural processes. Nevertheless, this approach has not been optimized and the neural process growth in response to growth factors has not been studied thoroughly. To address this issue, my research will focus on modulation of neural process motility on electrical and chemical stimuli to promote in-growth of neural processes. These patterned surfaces will also allow for more accurate replication of the complex architecture of various tissues and the examination of cell-cell and cell-substrate interactions, thus linking this line of research with my interest in surface engineering for implantable substrates. By controlling the areas in which cells can adhere to a substrate, cell spreading and shape can be controlled, ultimately affecting proliferation, differentiation, and gene expression.
   High sensitive bioanlytical platforms
Microarraying has been of great interest for biological analyte detection due to its multiplexed detection features. However, while relatively poor detection limits (in comparison to ELISAs) have hampered microarray use, current research has largely focused on the development of various fabrication techniques rather than on improving the detection limit. Compared to conventional ELISAs, the protocol of microarray immunoassay involves immobilization of pathogenic antigen on a solid substrate. Our research will focus on the precise control of protein-substrate interaction to improve microarray-based biological analyte detection. Well defined organization of biomolecules at the nanometer-to-micron length scale will contribute greatly to the development of an ‘integrated lab on a chip, potentially used as a point-of-care devices in clinical diagnosis or antiterrorism.

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