美国克利夫兰州立大学招聘分子生物学博士后

The Molecular Parasitology and Chromosome Biology lab at Cleveland State University is looking for a highly motivated postdoctoral fellow with significant experience in cell biology, biochemistry and molecular biology techniques to study telomere functions. A strong publication record and good spoken and written English are essential. Previous experience working with proteomics is desirable. To apply, please forward a copy of CV and three recommendation letters to b.li37@csuohio.edu.

 

Our lab is interested in telomere structure and functions in a protozoan parasite, Trypanosoma brucei, which causes sleeping sickness in humans. Inside a mammalian host, T. brucei regularly switches its surface antigen, VSG, to evade the host’s immune attack. To ensure the effectiveness of this antigenic variation and to maximize its efficiency, T. brucei cells express a single type of VSG protein at any time. We have recently found that the telomere structure plays an important role in regulating subtelomere-located VSG expression. Specifically, we found that a telomere-associated protein, tbRAP1, is essential for silencing subtelomeric VSG genes (Yang et al. 2009. Cell 137:99-109). Our future work will be focused on studying telomere protein functions in antigenic variation.

 

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